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| First Name: | Franck | | Last Name: | Polleux | | Title: | Dr | | Advanced Degrees: | PhD | | Affiliation: | The Scripps Research Institute | | Department: | Department of Molecular and Cellular Neuroscience | | Street Address 1: | Dorris Neuroscience Center | | Street Address 2: | 10550 N. Torrey Pines Rd | | City: | La Jolla | | State/Province: | CA | | Zip/Postal Code: | 92037-1000 | Country/Territory: | U.S.A. | | Phone: | 858-784-8488 | | Fax: | 858-784-9860 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 1 May 2013]
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View all comments by Franck Polleux
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Alzheimer Disease, Neurodevelopmental Disorders (Down syndrome, etc.)
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Signal transduction, A-beta PP/A-beta, Animal Models, Neurobiology, Electrophysiology, Tau/Cytoskeleton, Genetics, Microscopy, Molecular and Cell biology
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My lab is focusing on the identification of signaling pathways underlying mammalian neuron development and neurodegeneration. We use combinations of molecular and cellular tools with mouse genetics to study neurodevelopment and neurodegeneration in vivo and in vitro. |
1. Mairet-Coello, G., Courchet, J., Pieraut, S., Courchet, V., Maximov, A., and Polleux, F. (2013). The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Abeta Oligomers through Tau Phosphorylation. Neuron 78, 94-108. PMID: 23583109
2. Charrier, C., Joshi, K., Coutinho-Budd, J., Kim, J.E., Lambert, N., de Marchena, J., Jin, W.L., Vanderhaeghen, P., Ghosh, A., Sassa, T., Polleux F. (2012). Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. Cell 149, 923-935. PMID: 22559944
3. Williams, T., Courchet, J., Viollet, B., Brenman, J.E., and Polleux, F. (2011). AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress. Proceedings of the National Academy of Sciences of the United States of America 108, 5849-5854. PMID: 21436046
4. Yi, J.J., Barnes, A.P., Hand, R., Polleux, F., and Ehlers, M.D. (2010). TGF-β signaling specifies axons during brain development. Cell 142, 144-157. PMID: 20603020
5. Guerrier, S., Coutinho-Budd, J., Sassa, T., Gresset, A., Jordan, N.V., Chen, K., Jin, W.L., Frost, A., and Polleux, F. (2009). The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell 138, 990-1004. PMID: 19737524
6. Bortone, D., and Polleux, F. (2009). KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner. Neuron 62, 53-71. PMID: 19376067
7. Barnes, A.P., Lilley, B.N., Pan, Y.A., Plummer, L.J., Powell, A.W., Raines, A.N., Sanes, J.R., and Polleux, F. (2007). LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell 129, 549-563. PMID: 17482548
8. Hand, R., Bortone, D., Mattar, P., Nguyen, L., Heng, J.I., Guerrier, S., Boutt, E., Peters, E., Barnes, A.P., Parras, C., Schuurmans C, Guillemot F and Polleux F. (2005). Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. Neuron 48, 45-62. PMID: 16202708
9. Seibt, J., Schuurmans, C., Gradwhol, G., Dehay, C., Vanderhaeghen, P., Guillemot, F., and Polleux, F. (2003). Neurogenin2 specifies the connectivity of thalamic neurons by controlling axon responsiveness to intermediate target cues. Neuron 39, 439-452. PMID: 12895419
10. Polleux, F., Morrow, T., and Ghosh, A. (2000). Semaphorin 3A is a chemoattractant for cortical apical dendrites. Nature 404, 567-573. PMID: 10766232
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